Heart Failure Cardioprotective and Antiapoptotic Effects of Heme Oxygenase-1 in the Failing Heart
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منابع مشابه
Cardioprotective and antiapoptotic effects of heme oxygenase-1 in the failing heart.
BACKGROUND Heme oxygenase-1 (HO-1) is an inducible stress-response protein that imparts antioxidant and antiapoptotic effects. However, its pathophysiological role in cardiac remodeling and chronic heart failure (HF) is unknown. We hypothesized that induction of HO-1 in HF alleviates pathological remodeling. METHODS AND RESULTS Adult male nontransgenic and myocyte-restricted HO-1 transgenic m...
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Heart Failure Cardioprotective and Antiapoptotic Effects of Heme Oxygenase-1 in the Failing Heart Guangwu Wang, MD, PhD; Tariq Hamid, PhD; Rachel J. Keith, MS; Guihua Zhou, MD, PhD; Charles R. Partridge, PhD; Xilin Xiang, MD, PhD; Justin R. Kingery, MS; Robert K. Lewis, MD; Qianhong Li, MD, PhD; D. Gregg Rokosh, PhD; Rachael Ford, BS; Francis G. Spinale, MD, PhD; Daniel W. Riggs, BS; Sanjay Sri...
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Heme oxygenase (HO)-1 converts heme to bilirubin, carbon monoxide, and iron. Our prior work has suggested a cardioprotective role for HO-1 in heart failure. To test whether HO-1 (heat shock protein 32) prevents cardiomyocyte apoptosis and cardiac dysfunction after ischemia-reperfusion (I/R), we generated transgenic mice overexpressing HO-1 in the heart under the control of the alpha-myosin heav...
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